I've got a storyline for the writers.
The tram is actually carrying a stolen sample of a new government chemical weapon. As the crash takes place the vial is broken releasing the nerve gas into the air, cue footage in every house and workplace or most of the occupants dying in tortured, agonising ways ie Rita vomiting up her own digestive tract, Liz bleeding to death from her eyes, Fiz slowly swelling up till she explodes, Gail's face sagging further till it actually falls off, Tyrone getting more stupid until he actually forgets to breath. The survivors band together to try and fight off the effects of the illness itself, and the attention of the now deformed mutants. Kirk comes out as an unlikely hero after decapitating that annoying Beccy bird with one of her own hoop earings; and he leads the motely crew to the safety of Southampton (where everyone seems to go to escape from Corrie); where they start new lives. Hayley becomes a hooker, and Roy is her pimp, Janet goes into politics, and Leanne becomes a daytime talk show host to rival Jeremy Kyle.
Just an idea though...