Yes - I do it frequently.
All I do is list as usual, then quote a price (checking on the Royal Mail website for prices) for postage and packing to a) Europe and b) worldwide.
It's not complicated at all, you just need to be aware of which countries aren't in the EU, as you have to put a little Customs sticker on the back for non-EU countries.
The only instruction I give is that if the winner doesn't have a UK address, they must pay me by PayPal.
I've sold all over the world - it's no different to selling in the UK.