I've been taking various nitrates, Ramipril, Atorvastatin, Bisoprolol and Amlodopeine for about twelve years now after two heart attacks and a dodgy CABG operation. About a year ago I started having achy muscles and a severe lower back pain problem - whether it's caused by the tablets or just ageing (I'm 66) I dont know. But if so, it's always difficult finding out which tablet is the problem one - especially after a lengthy period. Best to get your Gp to work out a phased withdrawal programme with you and see what happens - could take a few weeks tho! Good luck.