A fair few though not that I'd want to detail on here.
I had a horrible experience around Ancoats, ended up in club there with a group of people I knew (not the kind of place I'd ever have gone otherwise) and had my drink spiked, it took me ages to get out the club, nearly walked off a raised dancefloor though a random guy caught me in time, eventually got out, not realising there where two entrances/exits and ended up by a canal and a building site, couldn't get a taxi to pick me up as couldn't get my words out properly. Finally managed to see a main road and get back into the city centre (an hour later! Clarion should realise how mad it is it took that long). Struggled to get cash out a cash machine and get in a taxi who thankfully got me home. Remember it turning a corner and "moved" with it, ended up lying sideways on the back of the taxi and staying there as I couldn't get back up.
A horrible experience.