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Hi again drodrigue. I noticed your question below about pregnancy and breast tenderness-this link says tenderness can be a side effect of coming off depo-it's also a possible side effect of having it tho! it also links to page about the length of time it takes fertility to return after discontinuing depo. There are a lot of horror stories on the web about this drug, so any concerns you have would be best raised with a family planning nurse or GP.