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Cystic fibrosis
Can someone explain to me how chloride is transported through cells in people with cystic fibrosis?
From my understanding, the channel that transports chloride is blocked or doesn't function properly - therefore there is a net movement of water into cells - causing problems in the lungs, pancreas and sweat glands. But if chloride can't be transported, how is it absorbed and manage to reach these organs in the first place?
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and it certainly isnt intuitive as CF was around for a long time, and no-one as far as I know said - Oh this is obviously and easily explained on chloride fluxes
I think this was reviewed in the New England journal www.nejm.org but they will almost certainly want you to pay to read it.