Iron overload occurs when, after many years, the body absorbs an abundance of iron which builds up in organ tissues such as the heart and/or liver. Iron overload is a serious chronic condition that must be properly diagnosed and treated. Undiagnosed iron overload can lead to hemochromatosis � a potentially life-threatening disease.
Hemochromatosis occurs as a result of significant iron overload. In the U.S. more than one million people have hemochromatosis. While the majority of cases are genetic in origin, other non-genetic causes may occur such as complications from other blood disorders, chronic transfusion therapy, chronic hepatitis, and excessive iron intake.
What are the Symptoms of Iron Overload or Hemochromatosis?
While there is no distinct set of symptoms that indicate iron overload, early symptoms of iron overload or hemochromatosis include:
Fatigue
Weakness
Weight loss
Joint pain
Abdominal pain
As iron overload progresses, patients often experience:
Arthritis
Dyspnea or shortness of breath
Certain conditions are associated with the advanced stages of hemochromatosis. These conditions include:
Arthritis
Abnormal liver function
Glucose intolerance
Diabetes
Severe fatigue
Hypopituitarism
Hypogonadism
Cardiomyopathy and arrhythmia
Liver cirrhosis
Liver cancer
Heart failure
Gray or bronze skin pigmentation
Other factors may influence the progression of hemochromatosis. These factors include:
Excess iron in the diet
Alcohol consumption
Vitamin C intake
Infections
Iron lost through menstruation or blood donations
Environmental factors