Hi, i am on Prozac for menopause and have just started taking Black Cohosh as well, ok so far.
I think your wife is very wise not to take HRT. My mum died of Breast
cancer and was convinces the HRT caused it as it was a hormone based cancer.There is significant proof of this also.
I dont know how long your wife has been taking Prozac but it does make you feel worse when first taking it. I was given a dose too high (40mg and went back to the doctor in a bit of a state as i thought i was going mad as i felt really depressed/panicky and shaky (even though i have suffered with depression for years, they made me REALLY depressed). The dose was too high. I lowered to 10mg and after 2-3 weeks felt so much better. It doesnt make the symptoms dissapear but helped immensely. I have also suffered with depression for years and this is the only anti-depressant that has made me feel near to 'normal'.
I hope your wife starts to feel better soon - it would be interesting to know how she gets on.
Tracey.