ssri's like citalopram can send people a bit high if they are that way inclined. i can't promise that any other anti depressant (including sertraline) won't do the same, but it is a process of trial and error. 50mg is a small starting dose, so that's good and it is also an ssri - but a second choice of treatment after the obvious suspects (citalopram, fluoxetine etc). sertraline tends to work more like the older tri-cyclic anti depressants, so is a good choice if you have already had a reaction to others. if this doesn't pan out, i would recommend you try venlafaxine, duloxetine or agomelatine instead (and in that order, if possible). it took me ages to find the right drugs to keep me sane (i have psychotic depression) and it's worth all the trying and waiting to get it right. try and stay positive and report back to your gp or shrink if you have any issues. regards, lisa x