Osteoporosis Treatment

[ethandron]

Has anyone changed from oral alendronic acid once a week, to an injection of denosumab once every six months, for their osteoporosis treatment?
If you did, what was the criteria for you to change? Thanks.

[NoMercy]

Oral bisphosphonates need to be contra-indicated, poorly tolerated or radiologically proven to be inefficacious in order for the patient to be eligible for Denosumab.

If Denosumab is being used to treat osteoporosis I do believe it's still only licenced for treatment in women at 60mg subcutaneously ever 6 months.

If being used to treat bone mets, it is licenced for men and women at 120mg every 4 weeks.

It can only be initiated for osteoporosis by someone with a special interest in osteoporosis.

[ethandron]

I did know most of that NoM but thank you for taking the time to post.
I'm hoping to hear from someone who has personal experience of changing as I'm currently on a medication holiday from AA and reluctant to resume taking it when the time comes, although I will of course discuss this with my GP.

[NoMercy]

What were the T-scores on your last Dexa? If you've had a statistically significant increase in bone mineral density (unlikely but not impossible) they may not advise resuming treatment for another 5 years following the standard 2-year drug holiday.