Barry Nelson appeared in a live (ie not pre-recorded) version of Casino Royale on TV. I saw it on video a while back. It's pretty short and undistinguished. Bond was a Yank and Felix Leiter became a Brit called Clarence Leiter, as I recall. I'm not really expecting Daniel Craig to be any better, though.
I may be wrong about this, but I'm sure the first person to play Bond was Mr Blockbusters, Bob Holness who played him in a Radio play in 1952 (or something like that).