I recently interviewed Glen Sobel who plays drums in Alice Cooper's band, and is also a music lecturer on drums in an American university.
Glen told me that he can tell which of his students have grown up listening to 'live' drums, and which have listened to music with drums recorded using programmes such as Pro-Tools - it actually influences the way young drummers play.
As a long-time music fan and music journalist, I can usually, but not always, spot a programmed sound from a 'real' one, although I tend to notice in passing, and not make an effort to work it out.
As advised by others, I think the end product is the point - I am far less interested in the quality of the equipment that plays music to me, than the quality of the music I am hearing.
That approach extends to the way the music has been produced - if it moves and entertains me, I don't really care too much how it is created.