The House Of Commons is acknowledged as one of the last great bastions of sexism, and any woman MP is aware of that, and works round it.
This was a situation in the House Of Commons, and this was the Prime Minister speaking to an elected MP, not some joshing in a pub round the corner.
From my perception, Cameron attempted to be light-hearted, and ended up appearing rude - the major pitfall of the humourless.
There is a time to be jokey about interuptions - and a time to be serious - guess which format belongs in Parliament?
In my view, the Speaker was at fault for not admonishing Cameron the first time he said it, and furthermore for not insisting on order when it was clear that everyone was getting very noisy.
If Cameron thought he was being witty, he was wrong, and as an experienced politician, he should know better than to use throwaway remarks when the microphones and cameras are on.
He looked like a pompous nasty upperclass twit - and on this occasion, that is what he was.