inferior vaccines is largely tosh
oo - I wdnt say that at Porton Down ! Typhoid A and B vaccine were always crap ( dead bacterial ) for around 100y. we were even examined on why that was the case. O and H antigens ( hauche and ohne hauche) collapsed and covered the Vi ( virulence) which was the antigen they wanted but cd never get it exposed.
https://en.wikipedia.org/wiki/Kauffman%E2%80%93White_classification
You can see 1976 how I got a prize in all this
Cholera was as bad ( this isnt too technical or un-mimzy for AB is it ?) and it was only after De's paper showing it exuded an exotoxin, 1959 Nature that progress was made
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089045/
short translation in AB speak: foo yeah, foo !