21a. Time rotten stinker got cheap gifts (8) ??I?S?T?.
41a. Aurally rein in language (5) C?E??.
45a. Female ruler volunteers to inject nerve gas (7) ?S???N?
6d. Just being mumsy for the second half??N?Y.
8d. Tell of French and Scottish island rising (7) ?A?R???.
38d. Asian guide to have fizzy drink? Bet's off dad (6) ?????A.
49d. The compiler has Monet composition as a reminder (7) ?E?E?T?.
Thanks for any help