>>>You need to go into BIOS setup to set your route drive to E. Apparently.
What a strange answer (p.s. I assume you mean "root" drive). May apply to perhaps unix/linux but not Windows.
If he sets "E" as his "root" then how is he going to boot into the operating system if E is his boot drive.
Anyway it is probably best to keep your programs on the same drive as your operating system. If you put Windows on one drive, and your programs on another, and one of the drives fails for some reason, you will have a huge problem sorting out the mess.
If Windows and all your programs are on the same drive you can then take an "image" of your drive with some backup software and store it on an external drive. It is then much easier to restore everything from that image as everyting is one the one drive.
So basically install Windows and all your programs on the same drive.
p.s. Many programs have a default or simple path to take the default install but there is usually an option like "Advanced" or something like that during the install to allow you to change the drive, or folder, where the product is to be installed (and other install options). Very rare for a program not to have that option.