The speed does not effect the astronuats one jot. To remain at a constant speed requires a net force of zero on a body, therefore the astronauts do not feel anything and could potentially travel at any speed and do their job. Remember there is nothing like air resistance for them to contend with, as you would feel if you stuck your head out of a car travelling down a motorway
Although strictly speaking the astronauts are accelerating but this acceleration is v close to the gravitational force we all know and love anyway; any object that is inserted in to orbit is given a lateral motion relative to its position above the surface of the earth. And depending on what height the object is, the right amount of lateral speed will ensure that it is in a constant state of free-fall. All objects orbiting the earth are in freefall due to the earth's gravity, but they are freefalling in such a way that the surface of the earth is constantly falling away from the object (due to the earth being spherical). That is why all objects in a geostationary orbit are at the same height (about 35,000-40,000 km) as that is the height at which the speed of free fall matches the rotation of the earth's surface.