Since no one else has answered, here are a few of my thoughts to kick things off. I assume you are talking about managing the effects on people;
- Firstly, and most importantly, Senior Management must be actively and visibly supporting the change - even if they privately don't agree. If they are not behind the change, don't even start.
- Make sure you try to get the "buy in" of people affected, for example by describing the changed state, why it is better, and what is in it for them. You could even get them involved in describing the "better" state for themselves, but expert help may be needed for this to succeed.
- Concentrate on the people with whom you are more likely to succeed. Don't waste lots of energy trying to convert the cynics.
- Celebrate success and reward progress with tokens of recognition.
- Establish measures and publish the results.
- Make the changes in manageable steps, and regularly review progress.
- Choose some easy targets to get you started. Don't aim for the moon with the first step. This will surely fail, and everyone will say - see I told you it was a waste of time!!
Hope this gives some food for thought, and perhaps prompts other responses.