Beyond the big and the small there is the bigger and smaller. Within this spectrum of existents it is the smallest, most distant and unlikely bits which continue to elude the reach of our ever growing powers of observation.
Beyond that which actually does exist is nothing at all, ironically what much of the to do is about while evading the importance of what does matter, the growing context of things we do know about and have some ability to change.
Life is about growing and improving our understanding of what it means to be alive as opposed to wallowing in our ignorance and praying for a cosmic handout.