There is no such thing as a vacuum.
A vacuum is a total absence of matter. However the old saying "Nature abhors a vacuum" turns out to be truer than we could imagine.
There are such things as virtual particles. These are particles and their anti-particles which are continually being created and distroying each other very rapidly. A vacuum is in effect a seething mass of particles being created and distroyed.
This is the foundation of the idea of Hawking radiation around black holes where the particle pairs cannot recombine due to the black hole. It is also the basis of the Casimir effect - so we know that this is the case because we can measure them through this effect.
There's some stuff in Wikipedia but it's a bit technical try here:
http://particleadventure.org/virtual.html