Your best bet long term is probably going to be remove everything off the E drive, then delete the E drive and extend the C drive to use the space freed up.
The only problem with doing this is you'll have to identify exactly what is on the E drive and make sure it's not actually being used for anything. you said in your other post it's mainly pictures and itunes on there, so you'd need to find out if it's the active itunes data or just a backup. if it's just a backup then just copy it off onto something like a memory stick. similarly with the pictures, why are they on the E drive and not the C drive, if they have just been put there as a backup then they can be copied off elsewhere with no problems.
Once you are sure there is nothing on the E drive it can be removed and then the C drive made larger to make use of the free space.
http://www.petri.co.i...ndows-server-2008.htm
(the quick and dirty way to check to see if anything on the E drive is being used would be to remove the drive letter (E) allocated to it, then restart the computer and see if there are any errors and check to see if everything like itunes still works, then if there are any problems it's easy to re-allocate the drive letter back to the partition and sort the problems out)