The only thing that ever helped me at all and then only temporarily but for quite a while, was progestogen cream from these folk.
http://www.progesterone.co.uk/
This isn't a spam and I have no links with the firm in question. I presume that you wife has gone over to natural fibre clothing and nightwear, cool baths and showers, plenty of liquid to drink and cut down on caffeine?
I tried black cohosh, red clover, the vitamin mix, soya, hrt, Agnus castus, the lot, nothing helped except the progestogen cream and management things like natural fibre clothes and so on. It's not as bad as it was, it's been about 14 years now, about 5 before I actually stopped bleeding and the rest afterwards.