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medical abbers!!!
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Does anyone know why tinzaparin is given as a subcut and not an oral tablet? thanks
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ilove...sorry...I very rarely use the internet.......just experience and try to work it out.
My reply, was based on the fact that these anticoagulants like heparin etc have such large molecules that they are poorly absorbed through the GI ract.
ABers slaney and Lazygun are academic scientists and if they see your post, I am sure that they will give you the advice and links that you require.
My reply, was based on the fact that these anticoagulants like heparin etc have such large molecules that they are poorly absorbed through the GI ract.
ABers slaney and Lazygun are academic scientists and if they see your post, I am sure that they will give you the advice and links that you require.
Nothing much to add to Sqads response really. Poor absorption from the gut due in part to its size, and also its negative charge, mean that the best route of absorption is either via IV or subcut administration.
There is a recognition that LMWH is in many ways a superior anticoagulant to warfarin, the main problem with it being the need to administer LMWH IV or subcut. There has been some work done on adapting heparin by attaching it to a carrier molecule that would allow from absorption from the gut. Should they perfect this method, it would prove to be an extremely useful oral anticoagulant, but they still have some way to go, i think.
For general reference;
http://en.wikipedia.org/wiki/Heparin
Development of an oral heparin anticoagulant ;
http://www.thrombosisjournal.com/content/4/1/6
There is a recognition that LMWH is in many ways a superior anticoagulant to warfarin, the main problem with it being the need to administer LMWH IV or subcut. There has been some work done on adapting heparin by attaching it to a carrier molecule that would allow from absorption from the gut. Should they perfect this method, it would prove to be an extremely useful oral anticoagulant, but they still have some way to go, i think.
For general reference;
http://en.wikipedia.org/wiki/Heparin
Development of an oral heparin anticoagulant ;
http://www.thrombosisjournal.com/content/4/1/6