Well I live in Norfolk and it hasn't done me any harm being inbred. I can manage to wash my faces and clean both sets of teeth although having my hair cut is a but iffy, as I need two appointments at the same time!!!
Seriously, there is a very big difference between inbreeding and linebreeding. Linebreeding is the best way of confirming the best features in your puppies, and provided you know there are no major faults in the line then the matings you suggested are indeed recommended, such as grandfather to granddaughter or uncle to neice.
Outcrossing (breeding two unrelated dogs) can lead to problems that you didn't know were in the lines, and you also have the added problem that you don't know which parent they will take after.
Having said all that, I can't believe anyone would contemplate breeding such a breed as Akitas without knowing these things, as they are such a specialist breed to breed and find homes for. Do they know that there are more males Akitas put down by 18 months than there are left alive? What experience do they have in the breed, and are the dogs going to be shown or worked to prove their quality and how do they know the male puppy will turn out good enough to be bred from? And why would people want to buy puppies from a mating where the parents are 'unknown' - I would always recommend people go to
experienced breeders with successful stock.
If you have a bitch that is a decent specimen, has done a bit of winning and has a superb health and temperament record, then you might consider mating her to a top class dog in the hope of producing puppies that people will want for their blood lines, not just because they are cute fluffy puppies.
By the way I am not actually Norfolk born, just an immigrant!