I stayed at the Roosevelt, beautiful hotel but the room was very small and not as grand as the hotel itself, did for us but we were only there for a few days and only there to sleep. It was quite close to Time Square and near a great diner called the Red Flame which was brilliant.
If you want to go up the Empire State Building, go early. Queues can get big and it takes quite a while to get up there as you go up in stages and through quite a bit of security with scanners and such.
The top of the Rockerfeller Center at night was great to see everything lit up. We also went to the Hulton Ferry landing to look back to see the skyline all lit up, it was part of an open topped bus tour. We did a load of the bus tours, it was really warm then though, likely very cold in November. The guides are brilliant, you get to learn so much more than walking around yourself. There was a special night one.
We didn't want to bother with Ellis Island so just got the free Staten Island Ferry over and back to see the Statue of Liberty.
Have lots of low denomination notes around with you and get someone to fill you in on what tips are expected for what before you go so you are aware. We thought we gave a generous tip to a taxi driver and were told quite abruptly that it wasn't enough!
Where are you flying in to? We flew in to Newark and the taxi rank was great as it had marshalls who agreed the fare before you got in the taxi, we also had to pay the toll for getting in to New York. Was great to go in a proper yellow cab.